Building a better antipsychotic drug by treating schizophrenia's cause
In this week's Journal of Neuroscience, Pitt researchers report progress in understanding how drugs act on dopamine-producing neurons; could enable them to create more targeted treatments PITTSBURGH—The classic symptoms of schizophrenia – paranoia, hallucinations, the inability to function socially—can be managed with antipsychotic drugs. But exactly how these drugs work has long been a mystery. Now, researchers at Pitt have discovered that antipsychotic drugs work akin to a Rube Goldberg machine— that is, they suppress something that in turn suppresses the bad effects of schizophrenia, but not the exact cause itself. In a paper published in this week's Journal of Neuroscience, they say that pinpointing what's actually causing the problem could lead to better avenues of schizophrenia treatment that more directly and efficiently target the disease. "In the past five years or so, we've really started to understand what may be going wrong with the schizophrenic bra...